To investigate the changes and significance of p38MAPK in hippocampus of post-traumatic stress rats. Wistar rats
were randomly divided into 4 groups: control group, PTSD 1d group, PTSD 4d group and PTSD 7d group, 8 rats in each
group. PTSD group was used to establish SPS model. The behavioral indexes of the rats were measured by open field
experiment and Morris water maze. The reverse press of p38MAPK in hippocampus was detected by RT-PCR and Western
blot. The results showed that the levels of p38MAPK in the hippocampus of rats after stress were significantly increased(P<0.
05). The conclusion is that the increase of p38MAPK in the hippocampus of rats with post-traumatic stress disorder may lead
to the loss of learning and memory function.
Pang Yuting, Xing Wenlong, Zhang Guiqing.
Changes of p38MAPK in hippocampus of Rats after Post-travmatic stress. Journal of Shihezi University. 2017, 35(5): 580-584 https://doi.org/10.13880/j.cnki.65- 1174/n.2017.05.010
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